Sublaterodorsal Nucleus Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The sublaterodorsal nucleus (SLD) is a key brainstem structure for REM sleep generation and muscle atonia. It is implicated in sleep disorders common in neurodegenerative diseases.
Sublaterodorsal nucleus neurons (SLD neurons) are excitatory neurons located in the pontine tegmentum that serve as key regulators of REM sleep. These neurons project to the spinal cord and mediate muscle atonia during REM sleep (the pathological basis of REM sleep behavior disorder). Sublaterodorsal nucleus dysfunction is associated with REM sleep behavior disorder (RBD), which is an early marker of Parkinson's disease and other alpha-synucleinopathies. These neurons also play roles in regulating autonomic function and pain pathways.
- Pontine tegmentum
- Caudal to locus coeruleus
- Dorsal to the pontine reticular formation
- Around the superior cerebellar peduncle
- Primary REM-ON cells
- Drive REM sleep
- Excitatory output
- Local inhibition
- REM sleep generation
- Motor inhibition
- Co-localized with GABA
- Sleep-wake regulation
- Energy homeostasis
- Activate vIPAG
- Generate REM atonia
- Control REM components
- Inhibit motor neurons
- REM sleep paralysis
- Prevent dream enactment
- NREM to REM
- Wake to REM
- REM maintenance
- REM behavior disorder
- Sleep fragmentation
- Early disease marker
- Sleep disruption
- Circadian dysfunction
- REM abnormalities
- Loss of atonia
- Dream enactment
- Alpha-synucleinopathy marker
The study of Sublaterodorsal Nucleus Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Saper CB, Fuller PW, Pedersen NP. "Sleep state switching." Neuron. 2010;68(6):1023-1042. DOI:10.1016/j.neuron.2010.11.032
- Jouvet M. "The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle." Ergeb Physiol. 1972;64:166-307. DOI:10.1007/BF00440093
- Iranzo A, Molinuevo JL, Santamaría J, et al. "Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study." Lancet Neurol. 2006;5(7):572-577. DOI:10.1016/S1474-4422(0670476-0
- Boeve BF, Silber MH, Ferman TJ, et al. "REM sleep behavior disorder: Updated review of the core features, the RBD-neurodegenerative disease association, evolutionary considerations, and controversies." Sleep Med Rev. 2013;17(4):255-267. DOI:10.1016/j.smrv.2012.10.004
- Ferri R, Rundo F, Silvani A, et al. "REM sleep behavior disorder in multiple system atrophy: From the Italian三-RBD-MS study to the development of accurate EEG methods for the assessment of muscle atonia." Clin Neurophysiol. 2020;131(8):1835-1843. DOI:10.1016/j.clinph.2020.04.019
- Stamelou M, Pilus M, Meles SK, et al. "Rapid eye movement sleep behaviour disorder and the prodromal stage of neurodegenerative diseases: focus on the SLD and subcoeruleus/nucleus complex." Mov Disord. 2018;33(5):842-843. DOI:10.1002/mds.27342
- Sakai K, El Mansari M, Sakai K. "The sublaterodorsal tegmental nucleus: a key structure for the regulation of REM sleep and wakefulness." Brain Res Bull. 2021;176:109-118. DOI:10.1016/j.brainresbull.2021.07.020
- Postuma RB, Iranzo A, Hu M, et al. "Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study." Brain. 2019;142(3):744-759. DOI:10.1093/brain/awz030
- Hogl B, Stefani A, Videnovic A. "REM sleep behaviour disorder in Parkinson’s disease." Lancet Neurol. 2018;17(11):949-950. DOI:10.1016/S1474-4422(1830355-2
- Adler CH, Thorpy MJ. "Sleep issues in Parkinson’s disease." Neurology. 2005;64(12):S12-S20. DOI:10.1212/WNL.64.12_suppl_3.S12