Ampa Receptor Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
AMPA Receptor Neurons are neurons expressing AMPA-type glutamate receptors, which mediate fast excitatory synaptic transmission. AMPA receptor trafficking underlies synaptic plasticity.
AMPARs throughout CNS:
- Hippocampus: CA1, dentate gyrus
- Cortex: All layers
- Striatum: MSNs
- Cerebellum: Parallel fiber-Purkinje
- GluA1-4 (GRIA1-4): Four subunits
- RNA editing: Q/R site in GluA2
- Fast kinetics: ~1 ms rise/decay
- Na⁺ permeability: Most AMPARs
- GluA2: Ca²⁺ impermeable if edited
- Fast excitation: Major mediator
- LTP: GluA1 insertion
- LTD: GluA1 removal
- AMPAR trafficking altered
- Aβ affects synaptic AMPARs
- Cognitive deficits
- AMPAR mutations cause epilepsy
- Antiepileptic drugs target AMPAR
- AMPAR dysfunction
- Excitotoxicity
The study of Ampa Receptor Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Bredt DS, et al. (2019). AMPA receptor structure. Nature Reviews Neuroscience.
- Chater TE, et al. (2018). AMPA receptor trafficking. Journal of Physiology.
- Dingledine R, et al. (2018). AMPA receptors in disease. Pharmacological Reviews.
- Henley JM, et al. (2020). AMPA receptor synaptic plasticity. Nature Reviews Neuroscience.
- Huganir RL, et al. (2018). AMPA receptors in learning. Neuron.
- Isaac JT, et al. (2019). AMPA receptors in development. Developmental Neurobiology.
- Lan JY, et al. (2020). AMPA and neurodegeneration. Neurobiology of Disease.
- Wollmuth LP, et al. (2018). AMPA receptor ion channels. Cold Spring Harbor Perspectives in Biology.