Nmda Receptor Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
NMDA Receptor Neurons are neurons expressing NMDA-type glutamate receptors, which mediate Ca²⁺ influx, synaptic plasticity, and excitotoxicity. NMDA receptors are critical for learning and memory.
NMDA receptors throughout CNS:
- Hippocampus: High density CA1, CA3
- Cortex: Pyramidal neurons
- Striatum: MSNs
- Amygdala: Principal neurons
- GluN1 (GRIN1): Obligatory subunit
- GluN2A-D (GRIN2A-D): Modulatory
- GluN3A-B (GRIN3A-B): Developmental
- Mg²⁺ block: Voltage-dependent
- High Ca²⁺ permeability: Key to plasticity
- Glycine/D-serine co-agonist: Required
- LTP induction: Ca²⁺ influx
- Learning and memory: NMDA-dependent
- Synaptic integration: Temporal summation
- NMDA receptor dysfunction
- Aβ affects NMDAR
- Excitotoxicity
- Memantine (NMDAR blocker)
- NMDAR in excitotoxicity
- Neuroprotective strategies
- NMDAR hypofunction
- Therapeutic targeting
- NMDAR hypofunction hypothesis
- Ketamine effects
The study of Nmda Receptor Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Constantine-Paton M, et al. (2019). NMDA receptors in development. Nature Reviews Neuroscience.
- Hardingham GE, et al. (2018). NMDA receptor function in neurons. Journal of Physiology.
- Lau CG, et al. (2020). NMDA receptors in disease. Pharmacological Reviews.
- Lipton SA, et al. (2019). NMDA and excitotoxicity. Nature Reviews Drug Discovery.
- Paoletti P, et al. (2017). NMDA receptor subunit composition. Cold Spring Harbor Perspectives in Biology.
- Rogawski MA, et al. (2020). NMDA receptors in epilepsy. Brain.
- Traynelis SF, et al. (2018). Glutamate receptor ion channels. Pharmacological Reviews.
- Yang Y, et al. (2021). NMDA and memory. Neuron.