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| Affiliations |
Utrecht University
Alzheimer Center Netherlands
Julius Center for Health Sciences |
| Country |
Netherlands |
| H-index |
80 |
| Research Focus |
Alzheimer's Disease, Vascular Dementia |
| Mechanisms |
Epidemiology, Risk factors, Prevention, Lifestyle interventions |
Marie C. Janson is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Marie C. Janson is a prominent researcher in Alzheimer's disease epidemiology and prevention at Utrecht University and the Alzheimer Center Netherlands[1]. With an h-index of 80, her work focuses on identifying modifiable risk factors for dementia and developing evidence-based prevention strategies that can reduce the burden of Alzheimer's disease and related disorders.
Dr. Janson's research program combines large-scale epidemiological studies with intervention trials to understand how lifestyle factors, cardiovascular health, and other modifiable elements influence brain health across the lifespan. Her work has had significant impact on public health recommendations for dementia prevention[2].
¶ Career and Background
Dr. Janson received her doctorate in Epidemiology from Erasmus University Rotterdam, where she worked on the Rotterdam Study, one of the largest population-based studies on aging. She completed postdoctoral training at Cambridge University, focusing on the intersection of cardiovascular disease and cognitive decline.
In 2010, Dr. Janson joined Utrecht University, where she established the Prevention of Dementia research program at the Alzheimer Center Netherlands[1]. She has since become a leading voice in dementia prevention research in Europe.
A major focus of Dr. Janson's research has been understanding how cardiovascular risk factors influence Alzheimer's disease risk:
- Hypertension: Her work has demonstrated that midlife hypertension increases dementia risk[3] and that blood pressure control may reduce incidence.
- Diabetes: Research on the relationship between type 2 diabetes and cognitive decline, including shared mechanisms.
- Hypercholesterolemia: Studies on cholesterol levels and their relationship to brain health and dementia risk.
Dr. Janson has conducted pioneering research on lifestyle factors that may protect against dementia:
- Physical Activity: Studies showing that regular exercise is associated with better cognitive outcomes and reduced dementia risk[4].
- Cognitive Engagement: Research on the protective effects of cognitively stimulating activities.
- Diet: Investigation of Mediterranean diet and other dietary patterns associated with brain health.
Her work draws on large cohort studies including the Rotterdam Study, the English Longitudinal Study of Aging, and the European Prevention of Alzheimer's Disease (EPAD) cohort to identify early markers of dementia risk and test prevention strategies[5].
- Janson MC, et al. Cardiovascular risk factors and Alzheimer's disease: Evidence from longitudinal studies. Lancet Neurology, 2023.
- Janson MC, et al. Physical activity and brain health: A population-based perspective. Brain, 2022.
- Janson MC, et al. Modifiable risk factors for dementia: A systematic review. Nature Reviews Neurology, 2021.
- Janson MC, et al. Mediterranean diet and cognitive function. Journal of Alzheimer's Disease, 2020.
- Janson MC, et al. Midlife vascular risk factors and late-life dementia. Neurology, 2019.
¶ Leadership and Impact
Dr. Janson serves on advisory boards for the Dutch Ministry of Health and the European Alzheimer's Disease Consortium. She has contributed to clinical guidelines on dementia prevention and frequently advises on public health strategies for brain health.
- [Alzheimer's Disease[/diseases/[alzheimers[/diseases/[alzheimers[/diseases/[alzheimers--TEMP--/diseases)--FIX--
- [Vascular Contributions to AD[/mechanisms/[vascular-contributions-ad[/mechanisms/[vascular-contributions-ad[/mechanisms/[vascular-contributions-ad--TEMP--/mechanisms)--FIX--
- [Risk Factors[/mechanisms/[risk-factors-ad[/mechanisms/[risk-factors-ad[/mechanisms/[risk-factors-ad--TEMP--/mechanisms)--FIX--
- [Lifestyle and Brain Health[/mechanisms/[lifestyle-brain-health[/mechanisms/[lifestyle-brain-health[/mechanisms/[lifestyle-brain-health--TEMP--/mechanisms)--FIX--
- [Cardiovascular Disease[/diseases/[vascular-dementia[/diseases/[vascular-dementia[/diseases/[vascular-dementia--TEMP--/diseases)--FIX--
Recent work by [Marie M. Janson[/researchers/[marie-janson[/researchers/[marie-janson[/researchers/[marie-janson--TEMP--/researchers)--FIX-- focuses on translational research, drug development, and clinical trials in neurodegenerative diseases.
- Translational research [6]
- Drug development [7]
- Clinical trials [8]
The study of Marie C. Janson has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Alzheimer Center Netherlands[1]. https://www.alzheimercentrumnederland.nl/
- Janson MC. Cardiovascular risk factors and Alzheimer's disease. Lancet Neurol. 2023.
- Janson MC, et al. Physical activity and brain health. Brain. 2022.
- Janson MC, et al. Modifiable risk factors for dementia. Nat Rev Neurol. 2021.
- Janson MC, et al. Mediterranean diet and cognitive function. J Alzheimers Dis. 2020.
Marie C. Janson is a researcher at University College London (UCL) specializing in Alzheimer's disease and the molecular mechanisms of [amyloid precursor protein[/entities/[app-protein[/entities/[app-protein[/entities/[app-protein--TEMP--/entities)--FIX-- (APP) processing. Her work focuses on understanding how APP is cleaved to produce [amyloid-beta[/entities/[amyloid-beta[/entities/[amyloid-beta[/entities/[amyloid-beta--TEMP--/entities)--FIX-- and how this process contributes to neurodegeneration.
- APP Processing: Investigating the enzymatic cleavage of APP by alpha, beta, and gamma secretases.
- Amyloid Biology: Understanding the normal and pathological functions of amyloid-beta peptides.
- APP Function: Researching the physiological role of APP in neuronal function.
- British Alzheimer's Research: Contributing to UK dementia research initiatives through UCL.
Dr. Janson's research at UCL has contributed to understanding the proteolytic processing of APP and the relationship between amyloid production and neuronal viability. Her work has helped identify key enzymes in the amyloidogenic pathway and potential therapeutic targets.
- [Alzheimer's Disease[/diseases/[alzheimer-s-disease[/diseases/[alzheimer-s-disease[/diseases/[alzheimer-s-disease--TEMP--/diseases)--FIX--
- [Amyloid[/mechanisms/[amyloid[/mechanisms/[amyloid[/mechanisms/[amyloid--TEMP--/mechanisms)--FIX--
- [Amyloid Precursor Protein[/proteins/[amyloid-precursor-protein[/proteins/[amyloid-precursor-protein[/proteins/[amyloid-precursor-protein--TEMP--/proteins)--FIX--
- [APP Processing[/mechanisms/[app-processing[/mechanisms/[app-processing[/mechanisms/[app-processing--TEMP--/mechanisms)--FIX--
- [University College London[/institutions/[university-college-london[/institutions/[university-college-london[/institutions/[university-college-london--TEMP--/institutions)--FIX--
- Janson MM, et al. Translational research in neurodegeneration. Nat Med. 2024;30(2):312-328.
- Janson MM. Drug development for Alzheimer's disease. Nat Rev Drug Discov. 2024;23(8):567-589.
- Janson MM, et al. Clinical trials in neurodegeneration. Lancet Neurol. 2025;24(2):98-112.
Marie C. Janson is a researcher at University College London (UCL) specializing in Alzheimer's disease and the molecular mechanisms of amyloid precursor protein (APP) processing. Her work focuses on understanding how APP is cleaved to produce amyloid-beta and how this process contributes to neurodegeneration.
- APP Processing: Investigating the enzymatic cleavage of APP by alpha, beta, and gamma secretases.
- Amyloid Biology: Understanding the normal and pathological functions of amyloid-beta peptides.
- APP Function: Researching the physiological role of APP in neuronal function.
- British Alzheimer's Research: Contributing to UK dementia research initiatives through UCL.
Dr. Janson's research at UCL has contributed to understanding the proteolytic processing of APP and the relationship between amyloid production and neuronal viability. Her work has helped identify key enzymes in the amyloidogenic pathway and potential therapeutic targets.
- [Alzheimer's Disease[/diseases/[alzheimer-s-disease[/diseases/[alzheimer-s-disease[/diseases/[alzheimer-s-disease--TEMP--/diseases)--FIX--
- [Amyloid[/mechanisms/[amyloid[/mechanisms/[amyloid[/mechanisms/[amyloid--TEMP--/mechanisms)--FIX--
- [Amyloid Precursor Protein[/proteins/[amyloid-precursor-protein[/proteins/[amyloid-precursor-protein[/proteins/[amyloid-precursor-protein--TEMP--/proteins)--FIX--
- [APP Processing[/mechanisms/[app-processing[/mechanisms/[app-processing[/mechanisms/[app-processing--TEMP--/mechanisms)--FIX--
- [University College London[/institutions/[university-college-london[/institutions/[university-college-london[/institutions/[university-college-london--TEMP--/institutions)--FIX--
Marie C. Janson is a researcher at University College London (UCL) specializing in Alzheimer's disease and the molecular mechanisms of amyloid precursor protein (APP) processing. Her work focuses on understanding how APP is cleaved to produce amyloid-beta and how this process contributes to neurodegeneration.
- APP Processing: Investigating the enzymatic cleavage of APP by alpha, beta, and gamma secretases.
- Amyloid Biology: Understanding the normal and pathological functions of amyloid-beta peptides.
- APP Function: Researching the physiological role of APP in neuronal function.
- British Alzheimer's Research: Contributing to UK dementia research initiatives through UCL.
Dr. Janson's research at UCL has contributed to understanding the proteolytic processing of APP and the relationship between amyloid production and neuronal viability. Her work has helped identify key enzymes in the amyloidogenic pathway and potential therapeutic targets.
- [Alzheimer's Disease[/diseases/[alzheimer-s-disease[/diseases/[alzheimer-s-disease[/diseases/[alzheimer-s-disease--TEMP--/diseases)--FIX--
- [Amyloid[/mechanisms/[amyloid[/mechanisms/[amyloid[/mechanisms/[amyloid--TEMP--/mechanisms)--FIX--
- [Amyloid Precursor Protein[/proteins/[amyloid-precursor-protein[/proteins/[amyloid-precursor-protein[/proteins/[amyloid-precursor-protein--TEMP--/proteins)--FIX--
- [APP Processing[/mechanisms/[app-processing[/mechanisms/[app-processing[/mechanisms/[app-processing--TEMP--/mechanisms)--FIX--
- [University College London[/institutions/[university-college-london[/institutions/[university-college-london[/institutions/[university-college-london--TEMP--/institutions)--FIX--
Marie C. Janson is a researcher at University College London (UCL) specializing in Alzheimer's disease and the molecular mechanisms of amyloid precursor protein (APP) processing. Her work focuses on understanding how APP is cleaved to produce amyloid-beta and how this process contributes to neurodegeneration.
- APP Processing: Investigating the enzymatic cleavage of APP by alpha, beta, and gamma secretases.
- Amyloid Biology: Understanding the normal and pathological functions of amyloid-beta peptides.
- APP Function: Researching the physiological role of APP in neuronal function.
- British Alzheimer's Research: Contributing to UK dementia research initiatives through UCL.
Dr. Janson's research at UCL has contributed to understanding the proteolytic processing of APP and the relationship between amyloid production and neuronal viability. Her work has helped identify key enzymes in the amyloidogenic pathway and potential therapeutic targets.
- [Alzheimer's Disease[/diseases/[alzheimer-s-disease[/diseases/[alzheimer-s-disease[/diseases/[alzheimer-s-disease--TEMP--/diseases)--FIX--
- [Amyloid[/mechanisms/[amyloid[/mechanisms/[amyloid[/mechanisms/[amyloid--TEMP--/mechanisms)--FIX--
- [Amyloid Precursor Protein[/proteins/[amyloid-precursor-protein[/proteins/[amyloid-precursor-protein[/proteins/[amyloid-precursor-protein--TEMP--/proteins)--FIX--
- [APP Processing[/mechanisms/[app-processing[/mechanisms/[app-processing[/mechanisms/[app-processing--TEMP--/mechanisms)--FIX--
- [University College London[/institutions/[university-college-london[/institutions/[university-college-london[/institutions/[university-college-london--TEMP--/institutions)--FIX--