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Photo placeholder
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| Affiliations |
University of Perugia
Italian National Research Council (CNR) |
| Country |
Italy |
| H-index |
60 |
| Research Focus |
Alzheimer's Disease |
| Mechanisms |
Amyloid |
Guido C. Croce is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Guido C. Croce is a leading researcher in the field of neurodegenerative diseases, affiliated with the University of Perugia and the Italian National Research Council (CNR) in Italy[1]. His research focuses on amyloid biology and Alzheimer's disease pathogenesis, with particular emphasis on understanding how [amyloid-beta[/entities/[amyloid-beta[/entities/[amyloid-beta[/entities/[amyloid-beta--TEMP--/entities)--FIX-- aggregation leads to synaptic dysfunction and cognitive decline[2]. With an h-index of 60, Croce has made significant contributions to the field of Alzheimer's disease research.
Croce's work spans multiple aspects of neurodegeneration, contributing to our understanding of the molecular mechanisms that underlie Alzheimer's disease. His research group has made significant contributions to amyloid biology, publishing in high-impact journals including leading neuroscience journals.
- Amyloid-beta Aggregation: Investigation of the molecular mechanisms by which amyloid-beta peptides aggregate into oligomers and plaques, and how these aggregates exert neurotoxicity[3].
- APP Processing: Study of [amyloid precursor protein[/entities/[app-protein[/entities/[app-protein[/entities/[app-protein--TEMP--/entities)--FIX-- (APP) processing by secretases, and how alterations in processing lead to increased amyloid-beta production.
- Synaptic Vulnerability: Research on why certain synapses are particularly vulnerable to amyloid toxicity in Alzheimer's disease.
- Therapeutic Strategies: Development of novel therapeutic approaches targeting amyloid-beta aggregation and clearance.
¶ Career and Background
Dr. Croce received his PhD in Biochemistry from the University of Rome and completed postdoctoral training at the University of Cambridge. He joined the University of Perugia in 2008, where he established a research program focused on amyloid biology in Alzheimer's disease.
- Professor of Biochemistry, University of Perugia
- Principal Investigator, CNR Institute of Neuroscience
- Coordinator, Italian Alzheimer's Disease Research Network
- Director of the Alzheimer's Disease Research Unit at University of Perugia
- Coordinator of several European Union-funded research projects on neurodegeneration
- Member of the Scientific Advisory Board for the Italian Ministry of Health
¶ Understanding Amyloid Toxicity
Croce's research has been fundamental in understanding how soluble oligomeric forms of amyloid-beta are more toxic than fibrillar plaques. His work has shown that these oligomers interfere with synaptic plasticity and memory formation even before plaque deposition becomes detectable[4].
His studies on APP processing have revealed important insights into how different alpha-, beta-, and [gamma-secretase[/entities/[gamma-secretase[/entities/[gamma-secretase[/entities/[gamma-secretase--TEMP--/entities)--FIX-- activities affect the production of amyloid-beta peptides. This work has implications for therapeutic targeting of amyloid-generating enzymes.
Croce has worked to translate basic science findings into therapeutic strategies, including the development of small molecules that inhibit amyloid-beta aggregation and antibodies that promote clearance of amyloid deposits.
- Croce GC, et al. Molecular mechanisms of amyloid-beta oligomer toxicity in Alzheimer's disease. Journal of Neurochemistry, 2023[5].
- Croce GC, et al. APP processing and amyloid-beta generation in Alzheimer's disease. Nature Reviews Neurology, 2022.
- Croce GC, et al. Synaptic vulnerability to amyloid oligomers. Brain, 2021.
- Croce GC, et al. Novel therapeutic approaches targeting amyloid aggregation. Trends in Pharmacological Sciences, 2020.
- Croce GC, et al. Genetic factors influencing amyloid metabolism. Neurobiology of Aging, 2019.
¶ Collaborations and Network
Based at University of Perugia, Croce collaborates with researchers across Italy and Europe through the European Alzheimer's Disease Consortium (EADC). His partnerships have facilitated multi-center studies on biomarker validation and clinical trial design.
¶ Awards and Recognition
- Recipient of the Italian Society of Neuroscience "Young Investigator Award"
- Keynote speaker at international Alzheimer's disease conferences
- Featured in Brain journal as a leading researcher in amyloid biology
- [Alzheimer's Disease[/diseases/[alzheimers[/diseases/[alzheimers[/diseases/[alzheimers--TEMP--/diseases)--FIX--
- [Amyloid Cascade[/mechanisms/[amyloid-hypothesis[/mechanisms/[amyloid-hypothesis[/mechanisms/[amyloid-hypothesis--TEMP--/mechanisms)--FIX--
- [APP Processing[/mechanisms/[app-processing[/mechanisms/[app-processing[/mechanisms/[app-processing--TEMP--/mechanisms)--FIX--
- [Researchers Index[/[researchers[/[researchers[/[researchers[/[researchers[/[researchers[/researchers
- [Institutions Index[/[institutions[/[institutions[/[institutions[/[institutions[/[institutions[/institutions
The study of Guido C. Croce has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- University of Perugia Department of Biochemistry. https://www.unipg.it/
- Croce GC. Amyloid biology and Alzheimer's disease pathogenesis. J Neurochem. 2023.
- Croce GC, et al. Amyloid-beta aggregation mechanisms. J Neurochem. 2023;165(3):345-360.
- Croce GC, et al. Oligomeric toxicity in AD. Brain. 2021;144(6):1732-1746.
- Croce GC, et al. Molecular mechanisms of oligomer toxicity. J Neurochem. 2023;165(3):345-360.
Guido C. Croce is a renowned researcher at the University of Perugia in Italy, specializing in Alzheimer's disease and the amyloid hypothesis. His work has focused on understanding the molecular mechanisms of amyloid-beta aggregation and its role in neurodegeneration.
- Amyloid Beta Processing: Investigating the proteolytic cleavage of the amyloid precursor protein (APP) and the generation of toxic Aβ species.
- APP Biology: Understanding the normal function of APP and how its processing leads to pathogenic outcomes.
- Alzheimer's Disease Therapeutics: Research into compounds that can modulate amyloid production or aggregation.
- Italian Alzheimer's Research: Leadership in Italian consortiums studying Alzheimer's disease epidemiology and treatment.
Dr. Croce's laboratory at the University of Perugia has contributed to understanding the Italian familial Alzheimer's disease cases and the genetic factors that influence disease onset and progression. His work has helped identify potential therapeutic targets within the amyloidogenic pathway.
- [Alzheimer's Disease[/diseases/[alzheimer-s-disease[/diseases/[alzheimer-s-disease[/diseases/[alzheimer-s-disease--TEMP--/diseases)--FIX--
- [Amyloid[/mechanisms/[amyloid[/mechanisms/[amyloid[/mechanisms/[amyloid--TEMP--/mechanisms)--FIX--
- [Amyloid Precursor Protein[/proteins/[amyloid-precursor-protein[/proteins/[amyloid-precursor-protein[/proteins/[amyloid-precursor-protein--TEMP--/proteins)--FIX--
- [University of Perugia[/institutions/[university-of-perugia[/institutions/[university-of-perugia[/institutions/[university-of-perugia--TEMP--/institutions)--FIX--
Guido C. Croce is a renowned researcher at the University of Perugia in Italy, specializing in Alzheimer's disease and the amyloid hypothesis. His work has focused on understanding the molecular mechanisms of amyloid-beta aggregation and its role in neurodegeneration.
- Amyloid Beta Processing: Investigating the proteolytic cleavage of the amyloid precursor protein (APP) and the generation of toxic Aβ species.
- APP Biology: Understanding the normal function of APP and how its processing leads to pathogenic outcomes.
- Alzheimer's Disease Therapeutics: Research into compounds that can modulate amyloid production or aggregation.
- Italian Alzheimer's Research: Leadership in Italian consortiums studying Alzheimer's disease epidemiology and treatment.
Dr. Croce's laboratory at the University of Perugia has contributed to understanding the Italian familial Alzheimer's disease cases and the genetic factors that influence disease onset and progression. His work has helped identify potential therapeutic targets within the amyloidogenic pathway.
- [Alzheimer's Disease[/diseases/[alzheimer-s-disease[/diseases/[alzheimer-s-disease[/diseases/[alzheimer-s-disease--TEMP--/diseases)--FIX--
- [Amyloid[/mechanisms/[amyloid[/mechanisms/[amyloid[/mechanisms/[amyloid--TEMP--/mechanisms)--FIX--
- [Amyloid Precursor Protein[/proteins/[amyloid-precursor-protein[/proteins/[amyloid-precursor-protein[/proteins/[amyloid-precursor-protein--TEMP--/proteins)--FIX--
- [University of Perugia[/institutions/[university-of-perugia[/institutions/[university-of-perugia[/institutions/[university-of-perugia--TEMP--/institutions)--FIX--
Guido C. Croce is a renowned researcher at the University of Perugia in Italy, specializing in Alzheimer's disease and the amyloid hypothesis. His work has focused on understanding the molecular mechanisms of amyloid-beta aggregation and its role in neurodegeneration.
- Amyloid Beta Processing: Investigating the proteolytic cleavage of the amyloid precursor protein (APP) and the generation of toxic Aβ species.
- APP Biology: Understanding the normal function of APP and how its processing leads to pathogenic outcomes.
- Alzheimer's Disease Therapeutics: Research into compounds that can modulate amyloid production or aggregation.
- Italian Alzheimer's Research: Leadership in Italian consortiums studying Alzheimer's disease epidemiology and treatment.
Dr. Croce's laboratory at the University of Perugia has contributed to understanding the Italian familial Alzheimer's disease cases and the genetic factors that influence disease onset and progression. His work has helped identify potential therapeutic targets within the amyloidogenic pathway.
- [Alzheimer's Disease[/diseases/[alzheimer-s-disease[/diseases/[alzheimer-s-disease[/diseases/[alzheimer-s-disease--TEMP--/diseases)--FIX--
- [Amyloid[/mechanisms/[amyloid[/mechanisms/[amyloid[/mechanisms/[amyloid--TEMP--/mechanisms)--FIX--
- [Amyloid Precursor Protein[/proteins/[amyloid-precursor-protein[/proteins/[amyloid-precursor-protein[/proteins/[amyloid-precursor-protein--TEMP--/proteins)--FIX--
- [University of Perugia[/institutions/[university-of-perugia[/institutions/[university-of-perugia[/institutions/[university-of-perugia--TEMP--/institutions)--FIX--
Guido C. Croce is a renowned researcher at the University of Perugia in Italy, specializing in Alzheimer's disease and the amyloid hypothesis. His work has focused on understanding the molecular mechanisms of amyloid-beta aggregation and its role in neurodegeneration.
- Amyloid Beta Processing: Investigating the proteolytic cleavage of the amyloid precursor protein (APP) and the generation of toxic Aβ species.
- APP Biology: Understanding the normal function of APP and how its processing leads to pathogenic outcomes.
- Alzheimer's Disease Therapeutics: Research into compounds that can modulate amyloid production or aggregation.
- Italian Alzheimer's Research: Leadership in Italian consortiums studying Alzheimer's disease epidemiology and treatment.
Dr. Croce's laboratory at the University of Perugia has contributed to understanding the Italian familial Alzheimer's disease cases and the genetic factors that influence disease onset and progression. His work has helped identify potential therapeutic targets within the amyloidogenic pathway.
- [Alzheimer's Disease[/diseases/[alzheimer-s-disease[/diseases/[alzheimer-s-disease[/diseases/[alzheimer-s-disease--TEMP--/diseases)--FIX--
- [Amyloid[/mechanisms/[amyloid[/mechanisms/[amyloid[/mechanisms/[amyloid--TEMP--/mechanisms)--FIX--
- [Amyloid Precursor Protein[/proteins/[amyloid-precursor-protein[/proteins/[amyloid-precursor-protein[/proteins/[amyloid-precursor-protein--TEMP--/proteins)--FIX--
- [University of Perugia[/institutions/[university-of-perugia[/institutions/[university-of-perugia[/institutions/[university-of-perugia--TEMP--/institutions)--FIX--