YOD1 (YOD1 Protease, also known as OTUD1) is a deubiquitinating enzyme belonging to the ovarian tumor (OTU) family. It functions as a deubiquitinase that cleaves K63-linked and linear polyubiquitin chains, regulating various cellular processes including protein quality control, autophagy, and stress responses.
| Property | Value |
|---|---|
| Gene | YOD1 / OTUD1 |
| UniProt | Q9GZP8 |
| Molecular Weight | ~52 kDa |
| Subcellular Localization | Cytosol, endoplasmic reticulum |
| Protein Family | OTU (Ovarian Tumor) deubiquitinase family |
YOD1 contains an N-terminal OTU domain with catalytic cysteine and a C-terminal extension. It interacts with the p97/VCP complex and other cofactors.
YOD1/OTUD1 plays important cellular roles:
YOD1 is a potential therapeutic target for:
Strategies include:
YOD1 regulates autophagosome-lysosome fusion. Nature Cell Biology. ↩︎
YOD1 modulates NF-κB signaling pathways. Cell Reports. ↩︎
YOD1 in parkin-dependent mitophagy. Journal of Biological Chemistry. ↩︎
Autophagy dysfunction in Alzheimer's disease and YOD1. Autophagy. ↩︎
YOD1 mutations cause hereditary spastic paraplegia. Brain. ↩︎