| VDAC1 Protein — Voltage-Dependent Anion Channel 1 | |
|---|---|
| Gene | [VDAC1](/genes/vdac1) |
| UniProt | P21796 |
| Molecular Weight | 31 kDa |
| Subcellular Localization | Mitochondrial outer membrane |
| Protein Family | VDAC/Porin family |
| PDB Structures | 3EMN, 4C9Q |
Vdac1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
VDAC1 (Voltage-Dependent Anion Channel 1) is the most abundant protein in the mitochondrial outer membrane and serves as the primary pathway for metabolite exchange between the cytosol and mitochondria. It plays critical roles in mitochondrial function, apoptosis, and has been implicated in neurodegenerative diseases.
VDAC1 is a 31 kDa beta-barrel protein with:
VDAC1 conducts:
VDAC1 interacts with:
In PD:
In AD:
The study of Vdac1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.