| USHER Syndrome 1G Protein | |
|---|---|
| Gene | USH1G |
| UniProt | Q9H0C8 |
| PDB | N/A |
| Mol. Weight | 130 kDa |
| Localization | Cell membrane |
| Family | SANS protein family |
| Diseases | Usher Syndrome |
Usher Syndrome 1G Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
USHER Syndrome 1G Protein is a protein encoded by the USH1G gene. It belongs to the SANS protein family family and has a molecular weight of approximately 130 kDa. This protein is localized to Cell membrane and plays a significant role in the pathogenesis of Usher Syndrome.
USHER Syndrome 1G Protein has been characterized structurally through X-ray crystallography and cryo-EM. Available PDB structures include: No structures deposited.
The protein's three-dimensional structure can also be explored via the AlphaFold Protein Structure Database.
Under physiological conditions, USHER Syndrome 1G Protein performs essential functions in the nervous system. It is primarily found in Cell membrane and contributes to normal cellular homeostasis, signaling, and neuronal function.
USHER Syndrome 1G Protein is implicated in the following neurodegenerative conditions:
Misfolding, aggregation, or dysfunction of USHER Syndrome 1G Protein contributes to neuronal damage through various mechanisms including proteotoxic stress, disrupted cellular signaling, and neuroinflammation.
USHER Syndrome 1G Protein represents an important therapeutic target. Multiple drug development programs are exploring strategies to modulate its function, reduce toxic forms, or enhance clearance mechanisms.
Publication list pending enrichment from PubMed.
The study of Usher Syndrome 1G Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Page auto-generated from NeuroWiki protein database. Last updated: 2026-02-26.