Ubisolin (UBSLN) is a stress-responsive protein involved in cellular protection against oxidative stress and proteotoxic stress. It plays a role in protein quality control and has been implicated in neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). [1]
| Gene | [UBSLN](/genes/ubsln) |
|---|---|
| UniProt ID | Q9Y5S9 |
| Protein Family | Ubiquitin-like domain-containing protein |
| Molecular Weight | ~52 kDa |
| Subcellular Localization | Nucleus, Cytoplasm |
| Expression | Ubiquitous, highest in brain |
Ubisolin contains multiple ubiquitin-like (Ubl) domains that facilitate interactions with proteasomal and autophagic machinery. The protein features:
The protein is conserved across mammals and is upregulated under various cellular stress conditions.
In the normal nervous system, Ubisolin participates in:
In AD, Ubisolin has been studied for its protective role against amyloid-beta (Aβ) toxicity:
In PD, Ubisolin may protect against alpha-synuclein aggregation:
In ALS, Ubisolin expression is altered in motor neurons:
| Partner | Interaction Type | Function |
|---|---|---|
| p62/SQSTM1 | Binding | Autophagy receptor |
| LC3 | Binding | Autophagosome formation |
| Proteasome | Binding | Protein degradation |
| Hsp70 | Co-chaperone | Protein folding |