| Ubiquilin-2 (UBQLN2) | |
|---|---|
| Gene | UBQLN2 |
| UniProt | Q9UHD9 |
| PDB | N/A |
| Mol. Weight | 66 kDa |
| Localization | Cytoplasm and nucleus; stress granules under stress |
| Family | Ubiquilin family |
| Diseases | ALS, Frontotemporal Dementia |
Ubiquilin 2 (Ubqln2) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Ubiquilin-2 (UBQLN2) is a protein encoded by the UBQLN2 gene. It belongs to the Ubiquilin family family and has a molecular weight of approximately 66 kDa1. This protein is localized to Cytoplasm and nucleus; stress granules under stress and plays a significant role in the pathogenesis of ALS, Frontotemporal Dementia.
Ubiquilin-2 (UBQLN2) has been characterized structurally through X-ray crystallography and cryo-EM. Available PDB structures include: No structures deposited.
The protein's three-dimensional structure can also be explored via the AlphaFold Protein Structure Database.
Under physiological conditions, Ubiquilin-2 (UBQLN2) performs essential functions in the nervous system. It is primarily found in Cytoplasm and nucleus; stress granules under stress and contributes to normal cellular homeostasis, signaling, and neuronal function.
Ubiquilin-2 (UBQLN2) is implicated in the following neurodegenerative conditions:
Misfolding, aggregation, or dysfunction of Ubiquilin-2 (UBQLN2) contributes to neuronal damage through various mechanisms including proteotoxic stress, disrupted cellular signaling, and neuroinflammation.
Ubiquilin-2 (UBQLN2) represents an important therapeutic target. Multiple drug development programs are exploring strategies to modulate its function, reduce toxic forms, or enhance clearance mechanisms.
The study of Ubiquilin 2 (Ubqln2) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.