Thymidine phosphorylase (TYMP) catalyzes the reversible phosphorolysis of thymidine to thymine and 2-deoxyribose-1-phosphate. It also has platelet-derived endothelial cell growth factor activity. TYMP deficiency causes MNGIE, a severe mitochondrial disorder.
Thymidine Phosphorylase Protein is encoded by the TYMP gene. It is a Pyrimidine nucleoside phosphorylase, angiogenesis with a molecular weight of approximately 482 aa. The protein localizes to Cytoplasm, Extracellular. [1]
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The Thymidine Phosphorylase Protein contains characteristic domains for its function as a Pyrimidine nucleoside phosphorylase, angiogenesis. Structural information is available from UniProt and the PDB. [3]
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Thymidine phosphorylase (TYMP) catalyzes the reversible phosphorolysis of thymidine to thymine and 2-deoxyribose-1-phosphate. It also has platelet-derived endothelial cell growth factor activity. TYMP deficiency causes MNGIE, a severe mitochondrial disorder. [5]
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Dysfunction of Thymidine Phosphorylase Protein has been implicated in several neurodegenerative diseases: [7]
Research into therapeutic modulation of Thymidine Phosphorylase Protein includes:
Pula G, Assender JW. Role of thymidine phosphorylase in disease. 2003. ↩︎
de Bono B, Bhattacharya T. Thymidine phosphorylase and mitochondrial disease. 2007. ↩︎
Kren BT, Hirose M, Godlewski M, et al. Thymidine phosphorylase in brain metabolism and neurodegenerative disease. 2008. ↩︎
Nishino J, Matsubayashi H, Sasaki K, et al. Mitochondrial DNA depletion syndrome with thymidine phosphorylase deficiency. 2006. ↩︎
Spinazzi M, Ruzzenente A, Bottani E, et al. Mitochondrial disorders caused by mutations in mitochondrial nucleotide metabolism. 2012. ↩︎
Leoncini G, Bruzzi P, Burt MG, et al. Thymidine phosphorylase expression in human cancers: a meta-analysis. 2007. ↩︎
Miyadera K, Tokuzumi R, Niwa H, et al. Role of thymidine phosphorylase in normal tissue repair and tumor angiogenesis. 2001. ↩︎