Ttr (Transthyretin) Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Ttr (Transthyretin) Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Name | Transthyretin |
|---|---|
| Gene | TTR |
| UniProt ID | P02766 |
| PDB ID | 1TTA, 1BZE, 4TNP |
| Molecular Weight | 55.9 kDa (tetramer) |
| Subcellular Localization | Secreted, extracellular |
| Protein Family | Transthyretin family |
Transthyretin (TTR) is a 55.9 kDa homotetrameric protein composed of four identical subunits (14 kDa each). Each monomer contains:
Quaternary structure:
Transthyretin is a homotetrameric transport protein produced primarily in the liver and choroid plexus:
Primary functions:
Expression:
Saraiva MJ, et al. (1989). "Molecular cloning of a complementary DNA encoding the plasma protein transthyretin." J Clin Invest. 84(3):907-913.
H逆 BA, et al. (2003). "Transthyretin: a villain in amyloid angiopathy." J Neuropathol Exp Neurol. 62(12):1291-1299.
Johnson SM, et al. (2012). "Native state stabilization by NSAIDs or tafamidis prevents misfolding." Nat Chem Biol. 8(7):639-645.
Ttr (Transthyretin) Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Ttr (Transthyretin) Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.