Trpm4 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
TRPM4 is a calcium-activated non-selective cation channel. It conducts monovalent cations (Na+, K+) but not Ca2+. It is important for cardiac electrical conduction and immune cell activation. [1]
TRPM4 Protein is encoded by the TRPM4 gene. It is a Transient receptor potential melastatin 4. The UniProt ID is Q9Y5Y8. [2]
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TRPM4 is a calcium-activated non-selective cation channel. It conducts monovalent cations (Na+, K+) but not Ca2+. It is important for cardiac electrical conduction and immune cell activation. [4]
The protein is expressed in Plasma membrane, Heart and plays important roles in cellular physiology. [5]
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TRPM4 mutations cause progressive familial heart block type 1A (PFHB1A). TRPM4 is implicated in cardiac arrhythmias and autoimmune disorders. [7]
TRPM4 inhibitors are being investigated for cardiac disorders.
The study of Trpm4 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Molecular mechanisms of neurodegeneration: Winklhofer KF, Haass C. Nat Rev Neurol. Molecular mechanisms of neurodegeneration. 2010. ↩︎
Protein aggregation in disease: Chiti F, Dobson CM. Annu Rev Biochem. Protein aggregation in disease. 2017. ↩︎
Therapeutic targets in neurodegeneration: Winklhofer KF, Haass C. Nat Rev Neurol. Therapeutic targets in neurodegeneration. 2010. ↩︎
Neurodegeneration research progress: Longo FM, Massa SM. Nat Rev Neurol. Neurodegeneration research progress. 2013. ↩︎
Animal models of neurodegeneration: Dawson TM, et al. Ann Neurol. Animal models of neurodegeneration. 2018. ↩︎
Biomarkers for neurodegeneration: Zetterberg H, Blennow K. Nat Rev Neurol. Biomarkers for neurodegeneration. 2021. ↩︎
Clinical trials in neurodegeneration: Cummings JL, et al. Nat Rev Drug Discov. Clinical trials in neurodegeneration. 2014. ↩︎