Treml2 Protein (Trem Like Transcript 2) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
:: infobox .infobox-protein
| TREML2 Protein (TREM-like transcript 2) | |
|---|---|
| Gene | TREML2 |
| UniProt | Q9GZL7 |
| Molecular Weight | ~28 kDa |
| Subcellular Localization | Cell surface, secreted |
| Protein Family | TREM family |
| Aliases | TREML2, TLT-2 |
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TREML2 (TREM-like transcript 2) is a protein involved in various cellular processes. This protein has been implicated in neurodegenerative diseases including Alzheimer's and Parkinson's disease.
TREML2 (TREM-like transcript 2) is a member of the triggering receptor expressed on myeloid cells (TREM) family. It is a single-pass type I membrane protein with an Ig-like V-type domain. The protein shares structural similarity with TREM2 but has distinct signaling properties.
TREML2 is expressed primarily in myeloid cells and regulates:
TREML2 is genetically associated with AD risk. Variants in TREML2 influence:
TREML2 plays a protective role in ischemic stroke by modulating inflammatory responses and promoting phagocytosis of debris.
Dysregulated TREML2 expression contributes to autoimmune and inflammatory conditions.
TREML2 agonists are being explored for:
The study of Treml2 Protein (Trem Like Transcript 2) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.