Tra2B Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Transformer 2 Beta | |
|---|---|
| Protein Name | TRA2B (Transformer-2 beta) |
| Gene | TRA2B |
| UniProt ID | Q13595 |
| PDB Structure | 2XU6 |
| Molecular Weight | 33 kDa |
| Subcellular Localization | Nucleus |
| Protein Family | Tra2 family |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
TRA2B is a 288 amino acid protein containing an RNA recognition motif (RRM) and an arginine/serine-rich (RS) domain. It binds to exonic splicing enhancers (ESEs) and promotes exon inclusion.
TRA2B functions as:
ALS-causing mutations in TRA2B disrupt normal splicing patterns, leading to inclusion of cryptic exons and loss of function. The RS domain is important for protein-protein interactions with other splicing factors.
The study of Tra2B Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.