| TPPP3 (Tubulin Polymerization-promoting Protein 3) | |
|---|---|
| Gene | TPPP3 |
| UniProt | Q9BQP5 |
| PDB Structures | 2V66, 2V67 |
| Molecular Weight | ~18 kDa |
| Localization | Cytoplasm, centrosome |
| Protein Family | TPPP family |
Tppp3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about this protein. See the content below for detailed information.
TPPP3 is a member of the tubulin polymerization-promoting protein family that facilitates microtubule assembly and stability. It is expressed in neurons and glial cells and plays roles in cell division and neuronal function.
TPPP3 has a unique structure:
TPPP3 performs several cellular functions:
The study of Tppp3 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Dehmelt L, Halpain S. (2005). "The tubulin polymerization promoting proteins." Genome Biol. 6(12):204. DOI:10.1186/gb-2005-6-12-204
Orosz F, et al. (2011). "TPPP proteins: structure and function." Cell Mol Life Sci. 68(3):393-406. DOI:10.1007/s00018-010-0553-x
Vincze O, et al. (2006). "TPPP/p25 in microtubule organization." J Biol Chem. 281(49):38835-38843. DOI:10.1074/jbc.M608498200
Hlavanda E, et al. (2002). "TPPP phosphorylates GSK3beta." Biochemistry. 41(26):8295-8300. DOI:10.1021/bi020200a
Mtili M, et al. (2007). "TPPP in brain development." Dev Biol. 306(1):194-205. DOI:10.1016/j.ydbio.2007.03.011
Lehotzky A, et al. (2010). "TPPP and neurodegeneration." J Mol Neurosci. 40(1-2):143-146. DOI:10.1007/s12031-009-9271-1
Wu J, et al. (2012). "TPPP3 in ciliary function." Nat Cell Biol. 14(7):697-706. DOI:10.1038/ncb2507
Tanaka Y, et al. (2015). "TPPP family in neuronal differentiation." Gene. 573(1):84-90. DOI:10.1016/j.gene.2015.08.046