| TMEM106B | |
|---|---|
| Gene | TMEM106B |
| UniProt | Q9NUM4 |
| PDB | N/A |
| Mol. Weight | 31 kDa |
| Localization | Late endosomes and lysosomes2 |
| Family | Type II lysosomal transmembrane protein family |
| Diseases | Frontotemporal Dementia, ALS3, LATE5 (Limbic-predominant Age-related TDP-43 Encephalopathy) |
Tmem106B is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
TMEM106B is a protein encoded by the TMEM106B gene. It belongs to the Type II lysosomal transmembrane protein family family and has a molecular weight of approximately 31 kDa1. This protein is localized to Late endosomes and lysosomes and plays a significant role in the pathogenesis of Frontotemporal Dementia, ALS, LATE (Limbic-predominant Age-related TDP-43 Encephalopathy).
TMEM106B has been characterized structurally through X-ray crystallography and cryo-EM. Available PDB structures include: No structures deposited.
The protein's three-dimensional structure can also be explored via the AlphaFold Protein Structure Database.
Under physiological conditions, TMEM106B performs essential functions in the nervous system. It is primarily found in Late endosomes and lysosomes and contributes to normal cellular homeostasis, signaling, and neuronal function.
TMEM106B is implicated in the following neurodegenerative conditions:
Misfolding, aggregation, or dysfunction of TMEM106B contributes to neuronal damage through various mechanisms including proteotoxic stress, disrupted cellular signaling, and neuroinflammation.
TMEM106B represents an important therapeutic target. Multiple drug development programs are exploring strategies to modulate its function, reduce toxic forms, or enhance clearance mechanisms.
The study of Tmem106B has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.