Path: /proteins/tctp-protein
Title: TCTP Protein (TCTP)
Tags: section:proteins, kind:protein
| TCTP Protein (TCTP) | |
|---|---|
| Gene | [TPT1](/entities/tpt1) |
| UniProt ID | P13693 |
| PDB Structures | 1YZ1, 2HRK, 4L7Z |
| Molecular Weight | ~19 kDa |
| Subcellular Localization | Cytoplasm, nucleus, secreted |
| Protein Family | TCTP family, translationally-controlled tumor protein |
| Length | 172 amino acids |
| Associated Diseases | Cancer, neurodegenerative diseases, autoimmune disorders |
TCTP (Translationally-Controlled Tumor Protein, also known as TPT1) is a 172-amino acid highly conserved protein involved in cell proliferation, survival, and stress responses[1]. It is ubiquitously expressed and functions as a multi-tasking protein with diverse cellular functions.
TCTP has a unique fold distinct from other known protein families:
The structure allows TCTP to interact with multiple protein partners.
TCTP performs diverse cellular functions:
TCTP alterations affect dopaminergic neuron survival:
TCTP is implicated in AD pathophysiology:
TCTP may play a role in motor neuron disease:
Bommer et al. Cell Death & Disease 2010. 2010. ↩︎
Li et al. Journal of Molecular Cell Biology 2012. 2012. ↩︎
Shalaby et al. Neurobiology of Aging 2014. 2014. ↩︎
Jung et al. Journal of Alzheimer's Disease 2018. 2018. ↩︎