{{Infobox
| image = TARDBP Structure
| infobox-header = TARDBP Protein
| infobox-subheader = TAR DNA-Binding Protein 43
| label1 = Gene
| data1 = TARDBP
| label1 = UniProt ID
| data1 = Q13148
| label2 = PDB Structures
| data2 = 2N4P, 2N4P, 2DTR
| label3 = Molecular Weight
| data3 = ~43 kDa
| label4 = Subcellular Localization
| data4 = Nucleus and cytoplasm; aggregates in cytoplasm in disease states
| label5 = Protein Family
| data5 = Heterogeneous nuclear ribonucleoprotein (hnRNP) family
}}
TARDBP Protein (TDP-43) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
TARDBP encodes TDP-43, a DNA/RNA-binding protein that is a major pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Abnormal aggregation of TDP-43 in cytoplasmic inclusions is a defining feature of approximately 95% of ALS cases and 50% of FTD cases.
TDP-43 is a 414-amino acid protein containing:
The protein undergoes multiple post-translational modifications including phosphorylation, ubiquitination, and cleavage into fragments in disease states.
TDP-43 is a ubiquitous nuclear protein with essential functions:
The study of Tardbp Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.