Synaptotagmin 1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Synaptotagmin-1 (SYT1) is a 421-amino acid synaptic vesicle membrane protein that functions as the primary calcium sensor for fast synchronous neurotransmitter release. It contains two C2 domains that bind calcium with high affinity.
| Attribute | Value |
|---|---|
| Protein Name | Synaptotagmin-1 |
| Gene | SYT1 |
| UniProt ID | P21579 |
| PDB ID | 1BYN, 1K5W |
| Molecular Weight | 47.5 kDa |
| Subcellular Localization | Synaptic vesicle membrane (presynaptic terminal) |
| Protein Family | Synaptotagmin family (16 members) |
Synaptotagmin-1 contains:
The C2 domains adopt β-sandwich folds typical of C2 domains.
In the nervous system, SYT1 functions as:
| Approach | Target | Status |
|---|---|---|
| Ca²⁺ channel modulators | Indirect modulation of SYT1 activation | Preclinical |
| Gene therapy | AAV-SYT1 for epilepsy | Research |
| Small molecules | Stabilize SNARE-SYT1 interaction | Research |
Synaptotagmin-1 mutations and dysregulation are linked to several neurological conditions:
SYT1 represents a therapeutic target for synaptic disorders:
Key research areas include:
The study of Synaptotagmin 1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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