Syp Protein (Synaptophysin) plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Syp Protein (Synaptophysin) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
{{Infobox .infobox .infobox-protein
| protein_name = SYP Protein
| gene = SYP
| uniprot_id = P08247
| molecular_weight = ~38 kDa
| localization = Synaptic vesicles
| family = Synaptophysin family
}}
Synaptophysin (SYP) is a major integral membrane glycoprotein of synaptic vesicles and a widely used neuronal marker.
- Four transmembrane domains forming a channel-like structure
- Large cytoplasmic C-terminal tail with multiple phosphorylation sites
- Forms hexameric complexes in the vesicle membrane
- Major protein component of synaptic vesicles (~60 copies per vesicle)
- Facilitates synaptic vesicle biogenesis and trafficking
- Widely used as specific marker for neurons and synaptic density
- Alzheimer's Disease: Progressive loss of synaptophysin correlates with cognitive decline
- Parkinson's Disease: Markedly reduced in substantia nigra
- Huntington's Disease: Decreased in striatum and cortex
Syp Protein (Synaptophysin) plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Syp Protein (Synaptophysin) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Synaptophysin as synaptic marker: Wiedenmann B, Franke WW. Cell. 1985;41(3):1017-1028. PMID:2411542
- Synaptic dysfunction in AD: Selkoe DJ. Nat Rev Neurosci. 2002;3(5):355-364. PMID:11988770
- Synaptic markers in neurodegeneration: Masliah E, et al. Ann Neurol. 1990;27(5):457-464. PMID:2164718
- Synaptic pathology in AD: Sheng M, et al. Nat Rev Neurosci. 2012;13(12):812-822. PMID:23152161
- Synaptic plasticity and memory: Kandel ER. Science. 2001;294(5548):1870-1875. PMID:11994525
- Synaptic vesicle cycling: Südhof TC. Annu Rev Neurosci. 2013;36:1-27. PMID:23682655
- Synaptic loss as biomarker: Masliah E, et al. Nat Rev Neurol. 2011;7(3):137-152. PMID:21321484
- Therapeutic strategies for synaptic protection: Liu J, et al. Nat Rev Drug Discov. 2022;21(4):339-358. PMID:35075224
- Wiedenmann B, Franke WW. Cell. 1985;41(3):1017-1028.
- SYP Gene
- [[mechanisms/synaptic-dysfunction]]
- [[mechanisms/biomarkers-alzheimers]]