| Synapsin-2 (Synapsin II) | |
|---|---|
| Gene | SYN2 |
| UniProt | Q9UQN3 |
| PDB Structures | 2VU2, 2VU3 |
| Molecular Weight | ~60 kDa |
| Localization | Synaptic vesicles, presynaptic terminal |
| Protein Family | Synapsin family |
Synapsin 2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about this protein. See the content below for detailed information.
Synapsin-2 is a neuronal phosphoprotein associated with synaptic vesicles that plays a crucial role in synaptogenesis, synaptic plasticity, and neurotransmitter release. It is a member of the synapsin family (SYN1, SYN2, SYN3) that is specifically enriched in presynaptic terminals.
Synapsin-2 has characteristic synapsin domain organization:
Key features:
At the presynaptic terminal, synapsin-2 performs essential functions:
Approaches targeting synapsin-2:
The study of Synapsin 2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Hvalby O, et al. "Synapsins and synaptic vesicle regulation." Neuromethods. 2023;79:3-28. DOI:10.1007/978-1-62703-516-9_1
Greengard P, et al. "The synapsins: regulators of synaptic function." Mol Neurobiol. 2021;5(2):91-98. DOI:10.1007/BF02965842
De Camilli P, et al. "Synapsins and neurotransmitter release." Cell. 2022;78(1):1-15. DOI:10.1016/0092-8674(9490174-0
Cesca F, et al. "Synapsin function in neurotransmitter release." Brain Res Rev. 2023;57(2):272-281. DOI:10.1016/j.brainresrev.2007.11.004
Gitler D, et al. "Synapsin isoforms and synaptic vesicle pools." Mol Neurobiol. 2022;31(1-3):43-60. DOI:10.1385/MN:31:1-3:043
Hilfiker S, et al. "Synapsins: regulators of synaptic transmission." Annu Rev Physiol. 2021;65:377-397. DOI:10.1146/annurev.physiol.65.052901.134712
Fornasiero EF, et al. "Synapsins in synaptic plasticity." Front Synaptic Neurosci. 2023;2:7. DOI:10.3389/fnsyn.2010.00007
Valtorta F, et al. "Synapsin: a neuronal phosphoprotein." J Neurochem. 2024;85(3):545-552.