Sumf1 Protein Sulfatase Modifying Factor 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Sulfatase Modifying Factor 1 | |
|---|---|
| Protein Name | Sulfatase Modifying Factor 1 |
| Gene | SUMF1 |
| UniProt ID | O75079 |
| PDB ID | 2YN8 |
| Molecular Weight | 42 kDa |
| Localization | Endoplasmic reticulum |
| Protein Family | Sulfatase modifier family |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
SUMF1 is an ER-resident enzyme:
SUMF1 catalyzes formylglycine formation:
SUMF1 mutations - combined sulfatase deficiency, severe neurodegeneration
Gene therapy approaches; enzyme replacement being explored
The study of Sumf1 Protein Sulfatase Modifying Factor 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.