Spastin Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Name | Spastin |
|---|---|
| Gene | SPAST |
| UniProt ID | Q9UBP0 |
| PDB ID | 3E86, 4Y4M, 6EPM |
| Molecular Weight | 60.6 kDa |
| Subcellular Localization | Cytoplasm, Nuclear membrane |
| Protein Family | AAA ATPase family |
Spastin is a 60.6 kDa AAA ATPase with multiple functional domains:
Spastin is involved in microtubule dynamics and membrane trafficking:
Primary functions:
Blackstone C, et al. (2011). "Hereditary spastic paraplegia." Lancet Neurol. 10(7):721-732.
Salinas S, et al. (2008). "Spastin and the ESCRT pathway: implications for neurodegeneration." Neurobiol Dis. 30(3):243-250.
The study of Spastin Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
SPAST encodes Spastin, a AAA ATPase involved in microtubule severing and axonal transport. Mutations cause hereditary spastic paraplegia.