Sorl1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Name | Sortilin-Related Receptor 1 |
|---|---|
| Gene | SORL1 |
| UniProt ID | Q9HAW0 |
| PDB ID | 3RHG, 5JYT |
| Molecular Weight | |
| 221.4 kDa | |
| Subcellular Localization | Endosome, Golgi, Cell surface |
| Protein Family | LDLR family, VPS10P domain receptors |
SORL1 (also known as LR11/SorLA) is a ~221 kDa type-1 transmembrane receptor:
SORL1 is a sorting receptor involved in protein trafficking and intracellular signaling:
Primary functions:
Expression:
Rogaeva E, et al. (2007). "The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease." Nat Genet. 39(2):168-177.
Andersen OM, et al. (2005). "Neuronal sorting protein SORL1 in Alzheimer disease." Nat Rev Neurol. 1(2):89-96.
Schmidt V, et al. (2012). "Quantitative modeling of amyloid precursor protein and SORL1 function." Nat Rev Neurol. 8(10):577-585.
The study of Sorl1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
SORL1 encodes Sorterin, a neuronal sorting receptor that regulates APP trafficking and amyloid-beta production. Variants are strong genetic risk factors for Alzheimer's disease.