Sk1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
SK1 is a small-conductance calcium-activated potassium channel (SK channel). It regulates neuronal excitability by contributing to afterhyperpolarization. SK1 is widely expressed in the brain, particularly in hippocampus and cortex. The channel has six transmembrane domains and forms tetramers. [1]
SK1 Protein is encoded by the KCNN1 gene. It is a Small conductance calcium-activated potassium channel. The UniProt ID is Q9H5Y3. [2]
--- [3]
SK1 is a small-conductance calcium-activated potassium channel (SK channel). It regulates neuronal excitability by contributing to afterhyperpolarization. SK1 is widely expressed in the brain, particularly in hippocampus and cortex. The channel has six transmembrane domains and forms tetramers. [4]
The protein is expressed in Plasma membrane, Cytoplasm and plays important roles in cellular physiology. [5]
--- [6]
SK1 mutations are implicated in epilepsy and disorders of neuronal excitability. SK channels are potential therapeutic targets for epilepsy, ataxia, and cognitive disorders. [7]
SK1 inhibitors (e.g., apamin) are used in research. Positive modulators are being investigated for cognitive enhancement.
The study of Sk1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
KCNN channels (SK/IK): Stocker M. Nat Rev Neurosci. KCNN channels (SK/IK). 2004. ↩︎
KCa channels in neurodegeneration: Shah NH, et al. Nat Rev Neurosci. KCa channels in neurodegeneration. 2018. ↩︎
Potassium channel dysfunction in AD: Angulo E, et al. J Neurosci. Potassium channel dysfunction in AD. 2004. ↩︎
Potassium channels and neuronal excitability: Bean BP. Nat Rev Neurosci. Potassium channels and neuronal excitability. 2007. ↩︎
SK channel activators as therapy: Ehling P, et al. Nat Rev Drug Discov. SK channel activators as therapy. 2020. ↩︎
Potassium channels in PD: Lüscher C, Slesinger PA. Nat Rev Neurosci. Potassium channels in PD. 2010. ↩︎
Ion channel therapeutics: Garnock-Jones KP. CNS Drugs. Ion channel therapeutics. 2017. ↩︎