{{ infobox .infobox-protein
| protein = SCFD1
| name = Sec1 Family Domain Containing 1
| gene = SCFD1
| uniprot = Q8WVF1
| molecular_weight = ~65 kDa
| localization = Cytosol
| family = Sec1/Munc18 (SM) protein family
| summary = Neuronal trafficking protein involved in synaptic vesicle release and neurodegeneration
}}
SCFD1 (Sec1 Family Domain Containing 1), also known as SIKE (Suppressor of IKBKE), is a member of the Sec1/Munc18 (SM) protein family[1]. SM proteins are essential regulators of membrane fusion events throughout the cell, particularly important in neuronal systems where they control neurotransmitter release.
SCFD1 is a cytosolic protein with the characteristic SM protein fold:
The SM protein family includes:
SCFD1 functions as a trafficking regulator in multiple pathways[2]:
In neurons, SCFD1 plays important roles in:
SCFD1 has been implicated in ALS pathogenesis[3]:
SCFD1 dysfunction contributes to neurodegeneration through:
Targeting SCFD1 function may provide therapeutic benefit: