SAM50 (Sorting and Assembly Machinery of the mitochondrial outer membrane 50) is a critical component of the mitochondrial outer membrane protein insertion machinery. SAM50 (also known as TOB55 or OMP85) facilitates the insertion of beta-barrel proteins into the mitochondrial outer membrane and is essential for mitochondrial function and cellular viability.
| Property | Value |
|---|---|
| Gene | SAMMC1 (SAMM50) |
| UniProt ID | Q9Y5W2 |
| PDB Structures | 4N9L, 5O8Y |
| Molecular Weight | ~50 kDa |
| Subcellular Localization | Mitochondrial outer membrane |
| Protein Family | OMP85/Bam family |
SAM50 contains:
SAM50 is a core component of the SAM complex (TOB complex):
SAM50 has been implicated in PD pathogenesis:
Gentle I, et al. Structure and function of the mitochondrial outer membrane protein import channel. Biochim Biophys Acta. 2007. ↩︎ ↩︎
Schapira AH. Mitochondrial dysfunction in Parkinson's disease. Cell Death Differ. 2007. ↩︎
Manczak M, et al. Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons. Hum Mol Genet. 2006. ↩︎