RPS7 (Ribosomal Protein S7) is an essential component of the 40S ribosomal subunit involved in translation elongation. The protein is encoded by the RPS7 gene located on chromosome 2p25.3 and is one of the most conserved ribosomal proteins across all domains of life 1.
| RPS7 Protein |
|---|
| Protein Name | Ribosomal Protein S7 |
| Gene | [RPS7](/genes/rps7) |
| UniProt | [P62081](https://www.uniprot.org/uniprot/P62081) |
| Location | 40S ribosomal subunit, ribosomal head |
| Function | Translation elongation |
| MW | 22.5 kDa |
RPS7 is located at the 40S ribosomal head and contains:
- An S7kh domain involved in rRNA binding
- Contact points with 18S rRNA
- Interfaces with transcription factors eIF2 and eIF3
RPS7 participates in 1:
- tRNA binding: Positions aminoacyl-tRNAs in the A-site
- mRNA binding: Facilitates codon reading and translocation
- Ribosome recycling: Helps dissociate post-termination complexes
- Quality control: Involved in nonsense-mediated decay
RPS7 is essential for 40S subunit maturation and is one of the primary assembly precursors.
RPS7 mutations cause Diamond-Blackfan anemia (DBA), a congenital erythroid hypoplasia. Haploinsufficiency of RPS7 affects erythropoiesis through p53 activation 2.
Translation dysregulation contributes to neuronal death in multiple neurodegenerative diseases 3.
- Global translation impairment in AD brains
- Ribosomal RNA oxidation reduces translation capacity
- Amyloid-beta causes ribosome stalling
- Alpha-synuclein affects ribosomal function
- ER stress impacts translation
- Mitochondrial dysfunction cascades to protein synthesis
- TDP-43 pathology disrupts translation regulation 3
- C9orf72 repeats cause nucleolar stress
- Global protein synthesis deficits in motor neurons
- eIF2α modulators: Reducing integrated stress response
- Ribosome-enhancing compounds: Improving translational capacity
- Aster: Translation of specific neuroprotective proteins
- Ribavirin: Modulating ribosome function