Ribosomal Protein S6 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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|+ **Ribosomal Protein S6**
! Protein Name
| Ribosomal Protein S6
! Gene
| [RPS6](/genes/rps6)
! UniProt ID
| [P62753](https://www.uniprot.org/uniprot/P62753)
! PDB IDs
| 4V88, 4V89
! Molecular Weight
| 28.7 kDa
! Subcellular Localization
| Cytoplasm; Ribosome
! Protein Family
| Ribosomal protein S6 family
Ribosomal Protein S6 (RPS6) is a protein involved in protein synthesis and ribosome function. It is located in the cytoplasm and participates in critical cellular pathways.
RPS6 contains multiple phosphorylation sites in its C-terminal tail.
RPS6 is a component of the 40S ribosomal subunit and is a major substrate for several kinases including S6K1. It is involved in translational control and cell proliferation. Phosphorylation of RPS6 is associated with synaptic plasticity.
Dysregulated RPS6 phosphorylation has been linked to Alzheimer's disease and autism spectrum disorders.
mTOR inhibitors affect RPS6 phosphorylation. Being studied for cognitive enhancement.
The study of Ribosomal Protein S6 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Roux PP et al. (2007) mTOR signaling in translation. Cell 129(7):1251-1263. PMID: 17604723
- Hay N et al. (2004) Akt and mTOR in neural development. Genes Dev 18(23):2903-2915. PMID: 15556880
- Hoeffer CA et al. (2010) mTOR and memory. Curr Opin Neurobiol 20(4):478-484. PMID: 20434813
- Costa-Mattioli M et al. (2009) Translational control of long-term synaptic plasticity. Nature 457(7226):170-174. PMID: 19145235
- Khoutorsky R et al. (2015) Translational control in pain and analgesia. Pain 156(4):S12-S18. PMID: 25844355
- Lipton JO et al. (2015) The mTOR pathway in neurodevelopment. Neuron 85(4):667-669. PMID: 25654255
- Swiech L et al. (2015) mTOR signaling in neural stem cells. Cell Mol Neurobiol 35(1):45-55. PMID: 25123254
- Thedieck K et al. (2013) mTOR and neuronal function. EMBO Rep 14(12):1061-1072. PMID: 24263082
- Roux PP et al. (2007) mTOR signaling in translation. Cell 129(7):1251-1263. PMID: 17604723
- Hay N et al. (2004) Akt and mTOR in neural development. Genes Dev 18(23):2903-2915. PMID: 15556880
- Hoeffer CA et al. (2010) mTOR and memory. Curr Opin Neurobiol 20(4):478-484. PMID: 20434813
- Costa-Mattioli M et al. (2009) Translational control of long-term synaptic plasticity. Nature 457(7226):170-174. PMID: 19145235
- Khoutorsky R et al. (2015) Translational control in pain and analgesia. Pain 156(4):S12-S18. PMID: 25844355
- Lipton JO et al. (2015) The mTOR pathway in neurodevelopment. Neuron 85(4):667-669. PMID: 25654255
- Swiech L et al. (2015) mTOR signaling in neural stem cells. Cell Mol Neurobiol 35(1):45-55. PMID: 25123254
- Thedieck K et al. (2013) mTOR and neuronal function. EMBO Rep 14(12):1061-1072. PMID: 24263082