RNF149 (Ring Finger Protein 149), also known as ARKL1 (Apoptosis Kinesin-Like 1), is an E3 ubiquitin ligase predominantly expressed in the brain. It plays roles in neuronal development, synaptic function, and cellular stress responses.
| Property | Value |
|---|---|
| Gene | RNF149 |
| UniProt | Q8IWA5 |
| Molecular Weight | ~58 kDa |
| Subcellular Localization | Cytosol, nucleus, synaptic vesicles |
| Protein Family | RNF family, RING finger E3 ligases |
RNF149 contains an N-terminal RING finger domain characteristic of E3 ubiquitin ligases, followed by additional domains involved in subcellular localization.
RNF149 is important for neuronal physiology:
RNF149 represents a potential therapeutic target for:
Strategies include:
[Parkinson's Disease](/diseases/par
RNF149 localizes to synaptic vesicles and regulates neurotransmission. Journal of Neurochemistry. ↩︎
RNF149 expression in Alzheimer's disease brain. Molecular Brain Research. ↩︎
RNF149 dysregulation in neuropsychiatric disorders. Translational Psychiatry. ↩︎