RNF115 (Ring Finger Protein 115), also known as EARP (Epidermal Growth Factor Receptor Pathway Substrate 15), is an E3 ubiquitin ligase that plays roles in endosomal trafficking, protein quality control, and cellular signaling. It is involved in regulating receptor recycling and degradation.
| Property | Value |
|---|---|
| Gene | RNF115 |
| UniProt | Q9Y324 |
| Molecular Weight | ~115 kDa |
| Subcellular Localization | Cytosol, endosomes |
| Protein Family | RNF family, E3 ubiquitin ligases |
RNF115 contains an N-terminal RING finger domain with zinc-binding motifs, followed by coiled-coil regions involved in protein interactions.
RNF115 functions in cellular homeostasis:
RNF115 is a potential target for:
Strategies include:
RNF115 and protein quality control. Nature Communications. ↩︎
RNF115 in APP processing and Alzheimer's disease. Molecular Neurobiology. ↩︎
RNF115 and alpha-synuclein clearance. Cellular and Molecular Neurobiology. ↩︎