Retromer Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Retromer Protein | |
|---|---|
| Protein Name | Retromer Complex |
| Genes | VPS26, VPS29, VPS35 |
| UniProt ID | Q9Y5W7, Q9Y5T5, Q9Y280 |
| Molecular Weight | ~170 kDa (complex) |
| Subcellular Localization | Endosomes |
The retromer is a coat complex that mediates retrograde transport from endosomes to the trans-Golgi network. It is essential for trafficking of cargo proteins including the amyloid precursor protein (APP) and the cation-independent mannose-6-phosphate receptor.
The study of Retromer Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
This section provides background information on the gene/protein and its role in the nervous system.
This overview section needs to be expanded with relevant scientific information from peer-reviewed sources.