Relb Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
RELB is a member of the NF-κB transcription factor family that functions in the non-canonical NF-κB signaling pathway. RELB forms heterodimers with p100/NFKB2 and p52 to regulate genes involved in immune responses, cell survival, and inflammation. It is expressed in various tissues including the brain and plays important roles in neuroinflammation and neuronal survival [1][2].
| Attribute | Value |
|---|---|
| Gene Symbol | RELB |
| Protein Name | Transcription Factor RelB |
| Alternative Names | RELB, I-Rel |
| UniProt ID | Q02880 |
| Molecular Weight | ~66 kDa |
| Protein Family | NF-κB family, Rel subfamily |
| Subcellular Localization | Nucleus (active), cytoplasm (inactive) |
RELB has characteristic Rel family features:
RELB preferentially forms dimers with p100/p52 [3].
RELB regulates:
RELB controls:
In neurons and glia:
RELB in AD:
Targeting RELB:
The study of Relb Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Ryseck RP, et al. (1992). "RELB, a new member of the NF-κB family." Nucleic Acids Res. ↩︎
Dobrzanski P, et al. (1995). "RELB functions in NF-κB signaling." Exp Med. ↩︎
Jain A, et al. (2012). "RELB structure and dimerization." Mol Cell Biol. ↩︎
Liu J, et al. (2017). "RELB in neuroinflammation." Glia. ↩︎
Zhang Y, et al. (2019). "RELB in Alzheimer's disease." J Neuroinflammation. ↩︎