Nf Κb P65 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Nf Κb P65 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [1]
| NF-κB p65 Protein | |
|---|---|
| Protein Name | NF-κB p65 Protein |
| Gene | [RELA](/genes/rela) |
| UniProt ID | [P06579](https://www.uniprot.org/uniprot/P06579) |
| PDB IDs | 1RAM, 1NFI, 2LMT |
| Molecular Weight | 65 kDa |
| Subcellular Location | Nucleus, Cytoplasm |
| Protein Family | [NF-κB](/entities/nf-kb) transcription factors |
NF-κB p65 Protein is a NF-κB transcription factors. The protein is involved in signal transduction and contains domains typical of NF-κB pathway components.
RELA (p65) is a key transcription factor subunit of NF-κB. It contains a REL homology domain for DNA binding and dimerization, and a transactivation domain for gene expression. RELA heterodimers (RELA/p50) are the predominant form of NF-κB. It regulates inflammatory cytokines (TNF-α, IL-1β, IL-6), anti-apoptotic proteins (BCL-XL, c-IAP), and adhesion molecules.
Chronic RELA activation drives neuroinflammation in AD, PD, and HD. RELA contributes to excitotoxicity and neuronal death. Mutations cause defects in immune response.
BAY 11-7082, NF-κB inhibitor (BAY 11-7085), IKK inhibitors, aspirin/NSAIDs (indirect).
Nf Κb P65 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Nf Κb P65 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Liu T, Zhang L, Joo D, Sun SC. NF-κB signaling in inflammation. Signal Transduction and Targeted Therapy. 2023. ↩︎