RAB28 (Ras-Related Protein Rab-28) is a member of the Rab GTPase family involved in intracellular membrane trafficking. The protein is encoded by the RAB28 gene located on chromosome 4q31.3 and is primarily expressed in retinal photoreceptor cells, though it is also found in brain tissue 1.
| Rab-28 Protein | |
|---|---|
| Protein Name | Ras-Related Protein Rab-28 |
| Gene | [RAB28](/genes/rab28) |
| UniProt | [Q9NPF7](https://www.uniprot.org/uniprot/Q9NPF7) |
| Location | Cytoplasm, membranes |
| Function | Membrane trafficking |
| MW | 24.5 kDa |
RAB28 contains the conserved Rab GTPase domain with Switch I and Switch II regions that undergo conformational changes during the GTP/GDP cycle. The protein has a C-terminal CVLL prenylation motif for membrane anchoring.
RAB28 plays critical roles in retinal function through:
RAB28 participates in endosomal trafficking pathways involved in protein sorting and recycling between cellular compartments.
RAB28 mutations cause inherited retinal diseases:
While RAB28 is primarily studied in retinal disease, Rab GTPases in general play important roles in PD through:
Rab GTPases contribute to AD pathogenesis:
Rab GTPases as a family are involved in: