Psma2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Name | Proteasome Subunit Alpha Type 2 |
| Gene | PSMA2 |
| UniProt ID | P25787 |
| PDB ID | 5MX3 |
| Molecular Weight | 25.9 kDa |
| Subcellular Localization | Cytoplasm, Nucleus |
| Protein Family | Proteasome alpha subunit family |
PSMA2 PROTEIN is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis. Dysfunction of PSMA2 PROTEIN is associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
PSMA2 is a 25.9 kDa subunit of the 20S proteasome α-ring. Like other α-subunits, PSMA2 has an N-terminal threonine catalytic site and participates in forming the substrate entry gate of the proteasome.
The 20S proteasome consists of four heptameric rings: two α-rings (PSMA1-7) and two β-rings (PSMB1-7). PSMA2 contributes to the structural integrity and regulatory functions of the α-ring.
PSMA2 contributes to proteasome function:
Proteasome modulation is being explored for neurodegeneration:
The study of Psma2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.