Presenilins are integral membrane proteins that form the catalytic core of the gamma-secretase complex.[1][2] In humans, the two principal paralogs are PSEN1 and PSEN2, both of which are central to amyloid precursor protein processing and familial Alzheimer's disease biology.
This page acts as a shared canonical target when source pages refer generically to “presenilin” rather than specifically to presenilin-1 or presenilin-2.[1:1][2:1] It links amyloid processing, intramembrane proteolysis, and broader Alzheimer's disease pathogenesis.
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 1 gene. Nature (1995). ↩︎ ↩︎
Gamma-secretase complex. Cold Spring Harbor Perspectives in Biology (2010). ↩︎ ↩︎