Ppp1Ca Protein (Protein Phosphatase 1 Alpha) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
:: infobox .infobox-protein
| PPP1CA Protein (Protein Phosphatase 1 Alpha) | |
|---|---|
| Gene | PPP1CA |
| UniProt | P62136 |
| Molecular Weight | ~38 kDa |
| Subcellular Localization | Cytoplasm, Nucleus |
| Protein Family | Protein phosphatase 1 family |
| Aliases | PPP1A, PP1 |
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Protein Phosphatase 1 Alpha (PPP1CA) is the catalytic subunit of protein phosphatase 1 (PP1), a member of the serine/threonine protein phosphatase family. PP1 is one of the most important phosphatases in eukaryotic cells, regulating numerous cellular processes including metabolism, synaptic transmission, cell cycle progression, and apoptosis. In the brain, PPP1CA plays critical roles in neuronal signaling, tau protein regulation, and synaptic plasticity, making it relevant to neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and Huntington's disease 1.
PPP1CA is the catalytic subunit of protein phosphatase 1 (PP1), a serine/threonine phosphatase. The protein consists of 330 amino acids and adopts a metalloenzyme fold with two metal ions (Mn²⁺) in the active site. PP1 forms holoenzymes with over 200 regulatory subunits that target it to specific subcellular compartments and substrates.
Protein phosphatase 1 is a major serine/threonine phosphatase involved in:
PPP1CA activity is altered in AD brain. The enzyme:
PP1 overactivity contributes to neuronal dysfunction in HD. Altered PP1 signaling affects:
PPP1CA dysregulation is common in cancers, affecting cell proliferation and survival.
PP1 inhibitors are being developed for:
The study of Ppp1Ca Protein (Protein Phosphatase 1 Alpha) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.