PNN (Pinin), also known as PNN (Pinin), is a nuclear and desmosome-associated protein involved in RNA splicing and cell adhesion. It plays important roles in neuronal cells by regulating alternative splicing and maintaining cellular junctions.
PNN is a protein of approximately 717 amino acids with a molecular weight of ~82 kDa. Key structural features include:
- RNAPII interaction domain: Binds to RNA polymerase II
- SR-rich regions: Serine/arginine-rich domains involved in splicing
- Desmosomal targeting domain: Localizes to cell-cell junctions
| Property |
Value |
| Gene |
PNN |
| Protein Name |
Pinin |
| UniProt |
Q9H7D9 |
| Molecular Weight |
~82 kDa |
| Length |
717 amino acids |
| Subcellular Localization |
Nucleus, Cytoplasm, Desmosomes |
| Protein Family |
PNN family |
PNN participates in multiple cellular processes:
- Alternative splicing regulation: Interacts with splicing factors to modulate splice site selection
- Transcriptional coupling: Connects transcription and splicing machinery
- Cell adhesion: Localizes to desmosomes in epithelial cells
- Neuronal function: Regulates splicing of neuronal transcripts
PNN dysfunction has been implicated in:
- Alzheimer's disease: Altered splicing of tau and APP transcripts
- Amyotrophic lateral sclerosis: Dysregulated splicing of TDP-43 targets
- Frontotemporal dementia: Abnormal RNA processing
- Aberrant splicing leads to inclusion of toxic exons
- Disrupted neuronal RNA processing
- Altered synaptic protein expression
- Splice-modulating oligonucleotides
- Small molecule splicing modulators
- RNA Splicing
- Alternative Splicing in Neurodegeneration
- SRRM4 Protein
- RBM25 Protein