PLIN2 (Perilipin 2) is a lipid droplet-associated protein involved in lipid storage and metabolism.
| PLIN2 (Perilipin-2 / Adipophilin) | |
|---|---|
| Gene | [PLIN2](/genes/plin2) |
| UniProt ID | [Q99541](https://www.uniprot.org/uniprot/Q99541) |
| PDB Structure | 6H54, 6B98 (cryo-EM lipid droplet structures) |
| Molecular Weight | 43 kDa |
| Subcellular Localization | Lipid droplet surface, endoplasmic reticulum |
| Protein Family | Perilipin family (PATs) |
PLIN2 (also known as adipophilin) is a member of the perilipin family of proteins that regulate lipid droplet dynamics[1]. The protein contains:
PLIN2 is a key regulator of cellular lipid metabolism:
PLIN2 is strongly implicated in Alzheimer's disease pathogenesis:
Kimmel, A.R. et al. (2010). The Perilipin Family of Lipid Droplet Proteins. Cellular and Molecular Life Sciences. 2010. ↩︎
Bickerton, A.S. et al. (2017). Structural Basis for Perilipin-2 Function. Journal of Biological Chemistry. 2017. ↩︎
Walther, T.C. & Farese, R.V. (2012). Lipid Droplets and Cellular Lipid Metabolism. Annual Review of Biochemistry. 2012. ↩︎
Lerch, J.K. et al. (2015). Altered Lipid Droplet Protein Expression in Alzheimer's Disease. Neurobiology of Aging. 2015. ↩︎
Zhang, X. et al. (2022). Ferroptosis in Alzheimer's Disease. Cell Death & Disease. 2022. ↩︎
Han, X. et al. (2021). Lipid Alterations in Alzheimer's Disease Brain. Molecular Psychiatry. 2021. ↩︎
Garcia-Garcia, R. et al. (2013). Lipid Metabolism in Parkinson's Disease. Journal of Parkinson's Disease. 2013. ↩︎
Liu, J. et al. (2017). C9orf72 Deficiency Promotes Lipid Accumulation. Nature Neuroscience. 2017. ↩︎
Block, R.C. et al. (2020). Lipid Dysregulation in Huntington's Disease. Brain Research Bulletin. 2020. ↩︎
Chandra, S. et al. (2022). Targeting Lipid Metabolism in Neurodegeneration. Nature Reviews Drug Discovery. 2022. ↩︎
Dyall, S.C. et al. (2017). Long-Chain Omega-3 Fatty Acids and the Brain. Proceedings of the Nutrition Society. 2017. ↩︎