Pka C Alpha Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Kinase A Catalytic Subunit Alpha | |
|---|---|
| Protein Name | PKA C-alpha |
| Gene | PRKACA |
| UniProt ID | P17612 |
| PDB ID | 1J3H, 2BCK |
| Molecular Weight | 40 kDa |
| Subcellular Localization | Cytoplasm, Nucleus |
| Protein Family | PKA family, Ser/Thr protein kinase |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Cushing's Syndrome |
PKA is a heterotetramer composed of:
The catalytic subunit contains:
PKA mediates cAMP signaling and regulates:
In Alzheimer's Disease:
In Parkinson's Disease:
In Cushing's Syndrome:
PKA modulators in development/clinical use:
The study of Pka C Alpha Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
This section provides background information on the gene/protein and its role in the nervous system.
This overview section needs to be expanded with relevant scientific information from peer-reviewed sources.