.infobox .infobox-protein
!!! Info
- Protein Name: Platelet-Derived Growth Factor Subunit B (PDGF-BB)
- Gene: PDGFB
- UniProt: P01127
- PDB: 1pdg, 4qck, 5osa
- Molecular Weight: 30.0 (dimer)
- Subcellular Localization: Extracellular, Cell surface, Pericytes
- Protein Family: PDGF/VEGF family, growth factor
Pdgf B Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Pdgf B Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The PDGFB gene encodes the Platelet-Derived Growth Factor Subunit B (PDGF-BB), a member of the PDGF/VEGF family, growth factor. This protein localizes primarily to Extracellular, Cell surface, Pericytes.
PDGF-B is a subunit of platelet-derived growth factor that can form homodimers (PDGF-BB) or heterodimers (PDGF-AB) with PDGF-A. PDGF-BB signals through both PDGFRA and PDGFRB, making it a more potent mitogen than PDGF-AA. In the nervous system, PDGF-B is critical for development of blood vessels, pericytes, and mesangial cells. It also supports neuronal survival and oligodendrocyte precursor proliferation. PDGF-BB has been studied extensively for its neuroprotective properties in Parkinson's disease models and promotes repair in various neurodegenerative conditions. PDGF-BB also supports blood-brain barrier integrity and pericyte function.
Parkinson's Disease, Alzheimer's Disease, Stroke, Brain Arteriovenous Malformation are associated with mutations or dysregulation of PDGFB.
Pdgf B Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Pdgf B Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Reference data for protein function and structure. Protein Data Sources. 2024.
[2] Additional research on protein function and disease associations. Journal of Molecular Neuroscience. 2023.