Park7 (Dj 1) Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Park7 (Dj 1) Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Name | Protein DJ-1 |
|---|---|
| Gene | PARK7 |
| UniProt ID | Q99497 |
| PDB ID | 1M0W, 1X4R, 3BXM |
| Molecular Weight | 20.0 kDa |
| Subcellular Localization | Cytoplasm, Nucleus, Mitochondria |
| Protein Family | DJ-1 family, ThiJ/PfpI family |
Parkin (PARK7), also known as DJ-1, is a 20 kDa protein belonging to the thiJ/PfpI family. The protein adopts a single alpha/beta fold with a conserved catalytic serine, forming a dimeric quaternary structure. DJ-1 has structural similarity to bacterial protease Hsp31 and contains:
DJ-1 is a multifunctional protein with diverse cellular functions:
Molecular functions:
Cellular localization:
Bonifati V, et al. (2003). "Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism." Science. 299(5604):256-259. DOI:10.1126/science.1077209
Kim RH, et al. (2005). "DJ-1, a novel regulator of neuronal viability, interacts with the mitochondrial protein Hsp75." Proc Natl Acad Sci USA. 102(41):14705-14710.
Lev N, et al. (2009). "DJ-1 protects against dopamine toxicity: implications for Parkinson's disease and addiction." J Neural Transm. 116(2):141-148.
Park7 (Dj 1) Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Park7 (Dj 1) Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.