P38 Alpha Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
P38 Alpha Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [1]
| p38 Alpha Protein | |
|---|---|
| Protein Name | p38 Alpha Protein |
| Gene | [MAPK14](/genes/mapk14) |
| UniProt ID | [Q16539](https://www.uniprot.org/uniprot/Q16539) |
| PDB IDs | 1P38, 1A9U, 2EWA |
| Molecular Weight | 41.3 kDa |
| Subcellular Location | Cytoplasm, nucleus |
| Protein Family | p38 MAPK family |
p38 Alpha Protein is a p38 MAPK family. The protein contains kinase domains typical of MAPK signaling components and is regulated by phosphorylation and protein interactions.
p38α is a serine/threonine kinase activated by cellular stress, cytokines, and inflammatory stimuli. p38 MAPK regulates inflammatory responses, cell cycle, apoptosis, and differentiation. In the brain, p38α is expressed in neurons and glia and contributes to neuroinflammation, amyloid-beta production, and tau pathology in AD.
p38α activation is implicated in AD (amyloid-beta production, tau pathology), PD (neuroinflammation), MS, and ALS.
SB203580, SB239063, PH-797804 (p38 inhibitors). Tested in clinical trials for inflammatory diseases. Potential for neurodegenerative disease treatment.
P38 Alpha Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of P38 Alpha Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Roskoski R. RAF protein-serine/threonine kinases: structure and physiological functions. Pharmacological Reviews. 2020. ↩︎