Purinergic Receptor P2Y12
| P2Y12 (P2Y12R) | |
|---|---|
| Gene | [P2RY12](/genes/p2ry12) |
| UniProt ID | [Q9H244](https://www.uniprot.org/uniprot/Q9H244) |
| PDB Structures | 4NTW, 4PXZ |
| Molecular Weight | 39.4 kDa |
| Subcellular Localization | Plasma membrane, microglial cells |
| Protein Family | G protein-coupled receptor (P2Y family) |
| Function | ADP receptor, platelet aggregation, microglial chemotaxis |
P2Y12 Protein is a protein. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
P2Y12 is a G protein-coupled receptor (GPCR) for ADP[1]:
P2Y12 is expressed primarily on microglia in the CNS:
P2Y12 on microglia mediates response to amyloid-beta[3]. The receptor is involved in microglial recruitment to plaques. Genetic variants may affect AD risk.
Microglial P2Y12 modulates neuroinflammation in PD. Targeting the receptor may provide neuroprotection.
P2Y12 contributes to microglial activation in demyelinating diseases. The receptor is a potential therapeutic target.
P2Y12 antagonists (clopidogrel) are antiplatelet drugs. Microglial P2Y12 may affect post-stroke inflammation.
| Drug | Target | Clinical Use |
|---|---|---|
| Clopidogrel | P2Y12 | Antiplatelet, stroke prevention |
| Prasugrel | P2Y12 | Acute coronary syndrome |
| Ticagrelor | P2Y12 | Antiplatelet therapy |
| Ticlopidine | P2Y12 | Stroke prevention |
Jacobson KA, et al. Structure of P2Y receptors. Nat Rev Drug Discov. 2014. ↩︎
Haynes SE, et al. P2Y12 in microglial surveillance. Nat Rev Neurosci. 2015. ↩︎
Moorhead G, et al. P2Y12 microglial response in AD. J Neurosci. 2019. ↩︎