== Structure ==
Otoferlin is a large transmembrane protein containing: [1]
Unlike synaptotagmins, otoferlin can directly mediate vesicle fusion without synaptotagmin, as it contains multiple C2 domains that can substitute for synaptotagmin function. [2]
== Normal Function == [3]
Otoferlin is essential for synaptic vesicle exocytosis in inner hair cells: [4]
== Role in Disease == [5]
== Therapeutic Targeting == [6]
== Key Publications == [7]
[Roux et al., Otoferlin is essential for Ca2+-triggered exocytosis is a protein. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target. [8]
== References == [9]
Michalski et al. Otoferlin gene therapy (2022). 2022. ↩︎
Yasunaga et al. [Otoferlin is essential for synaptic vesicle exocytosis (1999)](https://doi.org/10.1016/S0896-6273(00). 1999. ↩︎
Roux et al. Otoferlin mutations causing deafness (2006). 2006. ↩︎
Michalski et al. Otoferlin function in ribbon synapses (2009). 2009. ↩︎
Pawlowski et al. Otoferlin-mediated vesicle replenishment (2016). 2016. ↩︎
Strenzke et al. Synaptic vesicle fusion by otoferlin (2016). 2016. ↩︎
Safieddine et al. Otoferlin in auditory synapse function (2012). 2012. ↩︎
Stam et al. Otoferlin gene therapy for deafness (2015). 2015. ↩︎
Zhang et al. Otoferlin in hair cell synaptic transmission (2020). 2020. ↩︎