Optn Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| OPTN Protein | |
|---|---|
| Protein Name | Optineurin |
| Gene | OPTN |
| UniProt ID | Q9Y6K9 |
| PDB ID | 2R31 |
| Molecular Weight | 66 kDa |
| Subcellular Localization | Cytoplasm, Golgi, nucleus |
| Protein Family | TBK1 adaptor family |
OPTN is a 66 kDa protein with multiple domains: an N-terminal coiled-coil domain for self-interaction and TBK1 binding, a central LC3-interacting region (LIR), and a C-terminal ubiquitin-binding domain (UBD).
OPTN functions in multiple cellular processes:
The study of Optn Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
This section provides background information on the gene/protein and its role in the nervous system.
This overview section needs to be expanded with relevant scientific information from peer-reviewed sources.