Osmr Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
:: infobox .infobox-protein
| Protein Name | Oncostatin M Receptor (OSMR) |
| Gene | OSMR |
| UniProt ID | Q08357 |
| Molecular Weight | ~130 kDa |
| Subcellular Localization | Cell membrane |
| Protein Family | Type I cytokine receptor family |
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The Oncostatin M Receptor (OSMR) is a signaling receptor for Oncostatin M (OSM), a member of the IL-6 cytokine family. OSMR forms functional complexes with GP130 to mediate OSM signaling, which is involved in immune responses, inflammation, and cell survival. In the nervous system, OSMR contributes to neuroinflammation in neurodegenerative diseases.
OSMR is a type I cytokine receptor:
OSMR can form:
OSMR in AD:
OSMR in PD:
OSMR in ALS:
OSMR/OSM pathway is being explored:
The study of Osmr Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.