Ntrk1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Name | Tropomyosin Receptor Kinase A |
|---|---|
| Gene | NTRK1 |
| UniProt ID | P04629 |
| PDB ID | 1WWA, 2NRT, 4AT0 |
| Molecular Weight | 87.0 kDa |
| Subcellular Localization | Cell membrane |
| Protein Family | Trk family, Receptor tyrosine kinases |
TrkA is a receptor tyrosine kinase with the following domains:
TrkA is the high-affinity receptor for nerve growth factor (NGF):
Primary functions:
Signaling pathways:
Schecterson LC, et al. (2010). "Trk receptor and neurotrophin function." Trends Neurosci. 33(1):59-67.
Huang EJ, et al. (2003). "TrkA: a mechanistic and therapeutic target for Alzheimer's disease." J Alzheimer's Dis. 5(5):375-386.
The study of Ntrk1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
NTRK1 encodes TrkA, a receptor tyrosine kinase for NGF. Critical for neuronal survival and differentiation. Associated with neuropathy and neurodegeneration.